For the comprehensive control of an unstable slope in Lanzhou, by the use of anti-slide pile, soil retaining plank, pre-stressed anchor cable, passive protection net, active protection net, cutting (drainage) channel and backfill planting, the optimal combination of safety benefit, ecological benefit and economic benefit were achieved. Based on the analysis on regional engineering geological conditions, the paper puts forward the overall design ideas and introduces the design of various engineering measures as well as the construction points.