To accurately blast the local rock in a borehole is a technical knot in rock blasting. The solution of this problem may be helpful to obtain masses of minerals by way of boreholes and promote the efficiency of solution mining and in-situ uranium mining，and make it possible to obtain some difficult-to-mine minerals with significant potential value. A couple of blasting technical issues on rock fragmentation in borehole were discussed and the influencing factors were analyzed in this paper, it was indicated that well fragmentation of rock mass in-situ borehole could be achieved by way of adopting a reasonable loading means with full consideration of deposit conditions of rock.