The paper summed up the coring drilling experience in complex formation of poly-metallic miming area in Song County and emphatically introduced the comprehensive treatment measures of quartz grinding method for diamond bit slipping; drilling with simultaneous casing in weathered layer; different size casing for hole protection; wall cementing; 801 LCM, plant gum and sawdust for leaking stoppage. The construction cost was lowered and drilling efficiency was improved by these technical measures.