The effect of leakage stoppage has been affected the drilling speed of brine extraction well of alkali mine in Tongbai of Henan. By the leakage stoppage test with cement grouting in well SP08, it was found that the leakage characteristic of this stratum is fractured loss. Based on this characteristic and according to the laboratory test, a leakage stoppage technology for this region was systematically summed up in choice of leakage stoppage material and technology. A comprehensive technical measure and pressure sealing method mainly with high water loss material matching bridging blockage material was made to provide technical support in this mining area.