Diamond wire-line coring drilling and borehole protection by polyacrylamide non-dispersible solid-free fluid were used with several leakage control measures to deal with formation breaking, fracture development, leakage, collapsing, drill rod sticking and burying in Xihedaqiao gold mine of Gansu. The paper summed up the experience of drilling construction in this complex formation and put forward suggestions on reducing non-drilling time and improving drilling efficiency.