The construction is difficult because of complex formation structure in Southern Gansu with fault alteration development, structural development and extremely fractural zone development. Effective analysis and study were made on borehole structure, mud property, drilling technology and construction management, the suitable drilling scheme was established. The paper summed up the successful experience of drilling construction with wire-line coring drilling, bentonite mud making and non-disperse low solid mud technologies in Maquan goldmine.