Combining with the on-water exploration engineering example of Wuhu Yangtze river highway bridge，the paper summarizes the construction technology and construction safety management in deep and rushing river section. With the existing conditions, effective technical measures were adopted mainly according to the accurate anchoring and positioning of drilling platform; protecting casing fixation; bending, deformation and fracture of protecting hole casing; fluctuation of the water level and casing expansion, the drilling cost was greatly reduced and the good economic benefit and social benefit were obtained.