Scientific drilling hole NLDS-1 in Ganzhou is one of the 6 boreholes in the pre-research project on the location for CCSD. Because of the complex formations and serious natural bending, the wire-line core drilling was used with high viscosity and high density mud and the drilling trajectory was manually controlled for this borehole. The paper introduces the hole construction technology and innovation achievements, summarizes the experiences in the construction process and expounds the understandings from the technology in deep drilling.