It is a new trend to control landslide by using anti-sliding composite structure of micro-piles combined with other engineering measures, which has been largely applied in engineering practice for its convenient, low cost and high landslide stability being obviously increased by pressure grouting. Taking a landslide case of Xining-Jiuzhi highway as an example and based on the analysis on 2 existing slip zones of shallow layer and deep layer, a comprehensive landslide treatment measure is put forward: micro combined anti-sliding pile is applied with anchor frame beam consolidation and inclined drain holes. By the stability computation and rainfall test in rainy season, the feasibility and effectiveness of the comprehensive treatment measure by micro combined anti-sliding pile are proved.