High angle directional well can run through many oil reservoirs and increase oil and gas leakage area to improve the production of single well. Through the analysis on the difficulties in well Pu182-Xie154 construction, the casing program and the trajectory profile are optimized before the construction. Rational BHA and drilling parameters are selected together with the safety drilling technical measures of hole cleaning technology, friction resistance and torque reducing technologies and wellbore stability technology, which ensure the smooth construction of this high angle directional well.