ZK0401 is a deep hole in the salt rock survey project with designed depth of 3280m. In the coring drilling operation, according to the characteristics of water sensitivity formation, formation pressure and ground temperature, the successful experiment was made by drilling fluid with high temperature resistance and high density saturated salt water drilling fluid matching the suitable core drilling technology, hole terminal depth was 3286m, and the continuous salt rock coring was realized with good effects. The paper introduces the optimization of drilling fluid composition and the drilling fluid technology and measures in detail.