In Tarim basin, Paleogene and Cretaceous strata contain cream and salt with active gas show, cementing is difficult. Based on the summarization on cementing failure causes of anti-channeling slurry with slight expansion latex in early stage, the characteristics of stratum lithology are mainly considered. With the purpose of improving the quality of second interface cementation, the anti-channeling saltwater mud system is selected out. This mud system has the characteristics of small API fluid loss, small SPN value and high cement paste strength. The field application shows the good quality of cementation in cementing process.