TLSJD-1 is located in middle-lower Yangtze area. According to the general geology and construction requirements, proper construction organization and scientific and effective construction techniques were adopted. Deflection by screw motor was used for times in the construction to deal with the serious natural whipstocking. With self-developed 5-element drill tool to stabilize hole deviation, drilling trajectory was effectively controlled. In order to solve the instability of hole wall for open drilling of large section of mud shale in deep hole, under the condition of construction water with high salinity, a set of drilling fluid technology was summarized to ensure the smooth progress of the construction.