In the prospecting drilling construction project in complex formation of Yangzhai coal mine in Qianlong of Guizhou, the construction organization and management were carried out in the aspects of job responsibilities clarifying, detailed management procedures, strict examination of admittance conditions of construction team, selection of drilling methods and wall protection measures, proper use of flushing fluid and proper drilling operation, serious professional technical training, technical explanation before construction and technical instruction in the construction process. In this case, technical difficulties of collapsing while drilling in high gas and water gushing coal strata were overcome, the very difficult drilling project was completed successfully.