An investigation and evaluation on potassium mineral resources in Lenghuzhen of Qinghai Province is required by the project. There are large segments of halite and gypsum layer in the formation of Lenghu Town in Qinghai Province with loose stratum and high pressure coefficients. According to the special circumstances in this region, an salt resistance and collapse control non-dispersible flushing fluid was developed. The application shows that this flushing fluid has good salt and calcium tolerance, anti-sloughing and suspension property. The density of the flushing fluid should be adjusted according to the different formation pressure coefficients.