Baker Hughes commercially launched a new hybrid bit, Kymera bit, which combines features of a PDC and roller cone bit in Q4 2011. Kymera bit is especially suitable for difficult-to-drill formation, such as hard, stick-slip, hard-soft interbedded formations in shale plays, as well as for directional and horizontal well drilling. Kymera bit can increase ROP with roller cone’s ingressive capability in hard formation, improve PDC cooling condition, decrease torque fluctuation obviously, and also control well trajectory effectively. Kymera bit has been successful in oil and gas field applications in many counties. The development background of Kymera bit and case studies are given.