The 3709～4025m section of SX2 well in Tahe oilfield is in Permian igneous rock formation, where the fracture developed and several leakage happened in this 316m section and lower section during drilling process. Leakage could not be stopped by the efforts of bridging and cement plugging and the total loss occurred while drilling through the Permian at 5340m depth. The chemical consolidation plugging technology was used. The chemical consolidation slurry prepared by the chemical consolidation plugging agent has excellent properties such as high pressure bearing capacity (48h strength can reach above 17MPa), good temperature resistant (180℃) and good rheological property. This Permian leakage layer was divided into 2 sections and plugged by the chemical consolidation plugging technology, the pressure test presents that the pressure bearing capacity of the leakage layer is increased from 1.20g/cm3 to 1.56g/cm3, which meets the requirements of the subsequent drilling.