In order to reduce the high holing abandoned rate lasted for years in the construction of the southwest of Tarim, this paper introduces the drilling construction technology of Yundi well-1 in the southwest depression of Tarim basin, the process of dealing with complicated downhole situation and the on-site technical management measures; summarizes the technology characteristics of drilling in the complex strata of Tuyon basin in southwestern Tarim depression to form a complete set of feasible construction methods and technical management program, the construction problems in this region are basically solved.