Bad seepage behavior caused by high saturation line has become the main potential safety hazard of tailings pond, which is one of the most direct reasons of tailings dam-break accidents. The natural flow radiation well for seepage draining system has advantages of safe and reliable drainage, seepage collecting pipe horizontally reaching into wide range of the dam, large displacement, fast decreasing of water level, low cost, long service life and convenient final-period management. Natural flow radiation well has been applied to 2# radiation well in Yumugou tailings pond with remarkable technical and economic benefits. Combined with the construction practice, the research and discussion are made on the key construction technologies of natural flow radiation well for seepage draining system, which can provide the beneficial experience for the similar projects in future.