Youshashan oilfield is located at Qaidam basin, the complex geological structure, formation cracks development, low pressure coefficients, frequent leakage and long drilling cycle have seriously restricted the exploration and development benefits in conventional mud drilling. In view of these difficulties, aerated drilling tests are carried out in 4 wells, the results show that the aerated drilling can effectively solve the drilling problems in the leakage formation of Youshashan oilfield and improve the POP; compared with conventional mud drilling technology, the average plugging time is reduced by 6.32 days, the leakage loss is reduced by 54.5% and the ROP is increased by 1.1 times. The success of the tests are of guiding significance for the research and application in optimized and fast drilling technology in this block.