The conventional plain cement sealing material cannot fully meet the sealing requirements of the special geological formation with water gushing and gas bearing. Taking the sealing cement mortar as the research object, the proportion of cement mortar was designed by orthogonal experiment, the formula of the sealing material suitable for the water gushing and gas-bearing formation was obtained, and the technical requirements for borehole sealing quality are obtained. On the basis of laboratory experiments and combined with the specific formation conditions of Tongdi well1, the field application tests were carried out with the corresponding sealing material formula according to the sealing quality requirements of different well sections. The results show that the designed sealing material formula can meet the requirements of borehole sealing quality in the water gushing and gas-bearing formation.