With the exploration and development of oil and gas resources in tight reservoir in the East China Sea, the difficulties such as the deep buried reservoir, complex pressure system, poor drillability, long open hole, high deviation angle must be solved by means of the feasible technical solutions. Since 2012, safe and efficient drilling has been achieved by applying the deep well casing program optimization, high efficiency wear-resistant additive, cuttings bed removal technology, power-steering and composite impact drilling technology, wellhead reinjection cementing and acoustic logging while drilling for cementing quality evaluation technology during the implementation of the deep and ultra-deep wells in the East China Sea. The application of the above technology has an important role in drilling tight strata, improving the drilling rate, shortening the drilling period, reducing the operating cost and obtaining good economic and social benefits.