At present, the quantitative evaluation methods based on slope influence factors have their own limitations. Based on the monitoring data, multiple regression models are proposed to quantify slope influence factors. Through the fusion of the determined slope influence factors and the regression model, the problem of selecting and quantifying the influence factors in the process of slope stability evaluation is solved to a certain extent, which is beneficial to the establishment of an accurate slope stability analysis model. Finally, the model is applied in the slope of a reservoir accumulation body of a hydropower station, and the influence factors of the slope are quantified. The changes of the influence factors before and after Wenchuan earthquake are analyzed.