The No. 2 multi-branch horizontal well drilled from surface in Jiexiu Xinyugou Coal Mine, Shanxi, is a grouting hole where grouting technology is used to block the supply and replenishment passage of the Ordovician karst water. The actual drilling amount of the hole is 2194.86m, of which the vertical section is 490.27m, and the horizontal section 1704.59m. This paper introduces in detail of the main equipment, drilling fluid and drilling technology of the grouting hole, etc., and summarizes the difficulties and experience in drilling, which can provide reference for similar engineering construction.