Kazan Trona Mine in Turky is characterized by complicated geological settings, high content of insolubles in the primary mining layer and high dip angles of ore beds, which leads to frequently blockage problems during commercial solution mining. This paper takes Unit P078 horizontal intersected well as an example to describe the drilling techniques and leaching history, and analyze the causes of blockage. By following the principle of “from easy to difficult, minimizing risks and controlling the cost”, various attempts were taken to deal with the problem, such as single well circulation, pressurizing the channel by cementation truck, and circulating drilling mud to clean the borehole, and finally, it was decided that sidetracking was applied to drill a lateral to connect both targets, and it was proved to be successful with minimum costs and low risks. Some suggestions related to construction, design, repair and solution mining operations were put forward. The experience can provide some guidance and reference for solving blockage problems in the similar scenario.