Potable water supply is a vital problem that relates to the human health and social and economic development in Ghana. In order to solve this problem， many governments including China and international organizations initiated a couple of water well construction projects to improve the situation. Hubei Geological Engineering Co.， Ltd has overcome a variety of difficulties， completed over 4000 water wells in Ghana， and accumulated rich experiences in 21 years. In the paper， firstly the hydrological and geological settings， and the technical requirements of water wells in the country are introduced. Then， a set of drilling equipment which is suitable for the local conditions is put forwarded. For each of the 3 main rock types in Ghana， namely granite， phyllite， and quartz sandstone， a well drilling and well completion solution， covering open hole drilling， pilot hole drilling， reaming， RIH of screen pipes and backfilling gravel material is provided respectively.