At Danping Bauxite Mine in Zhengan county， Guizhou province， formation is broken and karst is developed， leading to drilling problems such as bit sticking by falling stones， difficult pull-up of casing. The drilling targets and tasks were completed on schedule through implementation of various technical measures， including optimization of the hole structure， proper selection of drilling parameters， combination of casing while drilling with wireline coring to provide wall protection in the karst cave deposit with higher borehole completion rate， sealing of borehole wall with polymer gel to reduces bit sticking in broken formation， use of reverse thread casing to reduce casing loss in collapsed formation with higher drilling efficiency and lower drilling cost， detection of spatial distribution of karst caves with the geophysical transient electromagnetic method to reduce the risk of encountering large karst caves. This paper sums up the drilling experience from the mine to provide reference for similar drilling works.