The Lower Shihezi Formation of Upper Paleozoic in Dongsheng Gas Field is a tight sandstone reservoir with good physical properties in some areas and natural production potential. There are problems of borehole wall failure and reservoir damage in the drilling process， and the reservoir damage caused by the combination of various factors hinders the release of gas productivity. In order to improve the natural production capacity of the reservoir， and increase the single well production， on the basis of reservoir permeability recovery， through analysis of the reservoir damage factors， the drilling fluid intrusion depth quantitative evaluation method was introduced to learn better the reservoir damage mechanism， and identify the low density， low water loss and soil-free phase and strong sealing drilling fluid as the solution. The waterproof locking agent and the tight pressure compound temporary plugging agent were selected in the laboratory to form a soil-free compound temporary plugging high acid soluble drilling fluid， increasing the permeability recovery to 91.11%， and reducing the mud intrusion depth by 46.28%. The drilling fluid was applied in the Jin-66 well area with the average single well production increased by 11%， and 3 wells realizing natural production； which has improved the effect of efficient exploration and development of tight sandstone reservoirs in Dongsheng Gas Field.