Well Weire-1 is a geothermal exploration well deployed by Department of Land and Resources of Henan Province in western Taikang Uplift, South North China. The designed depth of the well is 3000m with the completion depth of 3306.80m, which is the deepest geothermal well in South North China area. The fault was well developed, and the reference materials from adjacent wells were lacking. The geothermal geology research is not thorough and the formation is extremely complex, which are prone to collapse and block falling during drilling. In view of the difficulties in drilling works, optimization of drilling equipment, drilling parameter selection, drilling fluid systems was conducted. These measures have ensured the smooth implementation of drilling operations and provides reference and guidance for the construction of deep geothermal drilling in this area. In addition, Thermal reservoir thickness, lithology, porosity and permeability, water yield, hot water temperature and other parameters of the deep thermal reservoir in the area were obtained by analyzing the physical core data, logging data and pumping test data, and the development characteristics and development potential of deep heat storage in this area are revealed, which provides a guiding direction for future geothermal exploration and development.