Complex geological factors such as fractures, faults, weak surface structures in unconformity contact, and multiple pressure systems in Sichuan Chongqing region result in multi-layers and multi-mechanisms leakage in same open hole. In order to solve the problems of long plugging time caused by slow establishment of pumping channels for large-diameter plugging materials under traditional mode of replacing drilling tool assemblies for plugging operations and limited on-site application caused by poor stability of existing plugging tools. A repeatable on-off fast circulating valve that allows large-diameter plugging materials to pass through has been developed based on the working principle of quickly establishing a plugging channel by switching flow channels through ground injection of work balls. Through specific optimization designs of tool size, sliding sleeve structure, ball seat structure, basket and working ball group structure, the stability of tool structure is enhanced while matching the wellbore size and performance requirements of high-risk leakage section. It is allowed to use maximum material particle size of 10mm and maximum plugging slurry concentration of 40%. Based on the characteristics of different leakage type in long open hole section, a technical method for rapid plugging with fast circulating valves has been proposed, which involves multiple plugging methods for multi-leakage points encountered in longitudinal drilling and segmented plugging method for multi-leakage points simultaneously. The method can achieve plugging up to 5 leakage layers without tripping out and on-site test improved the efficiency of plugging operations by 74% and reduced the cost of plugging.