Wannandi Well—1 is a basic shale gas geological survey well deployed in Yandun Town, Nanling County, Anhui. This paper introduces in detail the drilling techniques and the treatment of the difficulties encountered in drilling, and analyzes the drilling efficiency with the relevant measures put forward for achieving quality and efficient drilling. With successful drilling of the well, the stratigraphic sequence in the southern Anhui area has been correlated, providing powerful physical data support and verification for the theoretical inference of shale gas reservoirs.