This paper mainly discusses some problems, such as low net drilling rate, frequent downhole incidents, encountered when drilling a hot spring well in alternate soft and hard sandstone/mudstone of the Xujiahe formation in Muchuan County, Southwest Sichuan. A drilling process with sliding and rotary PDM drilling was adopted to tackle the problems, leading to high drilling efficiency and economic benefits. It may provide some experience for large diameter deep hole drilling in the region in the future.