The horizontal well technology as an effective way to improve recovery and reduce development costs has been widely used at home and abroad. Development of horizontal wells in low-permeability reservoir can be several times the volume of the expansion of the reservoir drain, reduce the production of pressure, to increase crude oil production, however, the horizontal well cementing of the low-permeability reservoir has been difficult in the field. This paper focuses on the horizontal well cementing the status and difficult of the low permeability reservoirs in Shengli oil field, research ideas, optimized slurry system, the system has a zero-free water, low water loss, rheology, at right angles to thickening, micro-expansion, channeling the performance and strong features; Preferred the excellent performance of the wash prepad fluid, and cement slurry, drilling fluid compatibility, Using cementing measures to improve the quality of the horizontal well cementing in Shengli low-permeability reservoirs.