It is difficult to obtain all reservoir parameters due to complicate geological characteristics of the hydrate reservoir in the Shenhu area， South China Sea. In this study， by means of intelligent fitting， according to the actual gas yield in the trial production， the Shenhu Sea area in the South China Sea was selected as the target area， and depressurization mining was combined with vertical well network mining measures to improve the mining effect so as to solve the problem of energy shortage in China in the future. Due to the lack of precise values required for numerical simulation of hydrate reservoir parameters in the Shenhu area of the South China Sea， the reservoir physical property parameters were determined by the historical fitting method and long-term exploitation prediction was carried out to lay a foundation for subsequent hydrate exploitation experiments.