The paper introduces Hua'nan Highway engineering in Guangzhou city. The project includes several bridges, in which totally 112 pieces drill (wash) bored piles, with 1.0 m, 1.5 m and 1.8 m in diameter, 44 ~ 51 m in length, were adopted as the foundations. Because geological conditions varies largely, some strata contain mud layer and Karst cave etc. and what’s more, main bridge locating in water at the depth of 8 m, some difficulties were dealt with.