This paper firstly introduces the deep excavation’s engineering situation, geological and hydro-geological conditions of Wuhan University’s Science and Technology Incubator Building, and mainly introduces design train of thoughts of choosing different timbering precepts according to field’s circumjacent condition. And then, it presents processing method to control of ground water. Otherwise, it introduces requirements of construction monitor and measure of emergency treatment. Monitor and measure real time was carried out, which was designed to ensure construction process and circumjacent buildings all right.