Deep fractured gas reservoir has the characteristics of abnormal high pressure and high production, and in the well drilling and completion process, blowout and leaky accidents often occur, so leakage proof and blocking are necessary. Experiments were made with full-scale plugging devices in statistic and dynamic high-pressure simulated plugging and combination of optimized formulas; and systematic review was made on plugging capacity, resistance to pressure and acid solubility. The determined formula has the characteristics of high-rate of acid solution, high-strength of plugging and good effect of flow-back, which provides basis for on-site leakage proofing.