According to the hole-shrinkage, block-falling and collapsing in different formations of Chaganhua area, silicon-aluminum complex amphitricha polymer inhibition and anti-collapse drilling fluid system was developed. Laboratory test study was made on AOS-1 (silicon-aluminum complex inhibition and anti-collapse additive) with in-door water sensitivity, compatibility and roll recovery tests, which was applied in 6 wells of this area. Test results showed the good compatibility of the new strong inhibition drilling fluid to other treating agents with strong inhibition, and hole-shrinkage and collapsing were overcome.