According to the characteristics of lost circulation in drilling in Zhenjing oil field, the treatment methods were adopted for different cases. Time-controlled drilling and short pipe-trip was for the lost circulation in the quaternary loess layer, prevention and drilling with unidirectional pressure temporary plugging additive was for the lost in permeable sand-stone layer, composite cement slurry was for vertical fracture layer and bridge material + cementing was for serious loss. All of these lost circulation control technologies were proved effective.