The paper introduced the design of pre-stressed anchor cable reinforcement for K444+710～822 upline side slope of Guilin-Liuzhou highway. The design scheme demonstration was made on the basis of the analysis on landform and lithology, geological structure characteristics, climate and hydrogeology conditions and formation mechanism of slop deformation destruction, the best reinforcement plan was presented. It has been proved in several raining seasons that the plan was feasible.