The paper introduced the wall protection and leaking stoppage technical measures while drilling in Qaganqulu Mining Area of Keerqiyouyizhong Banner. According to the rock strata condition and the hole depth, wall protection and leaking stoppage by casing, drilling fluid and cementing were adopted with good effect and movable casing was safe and reliable for special rock formations. The tight mud cake formed with low solid-phase mud of sodium carboxymethyl cellulose (CMC) + hydrolyzed polyacrylamide (PHP) could stop block falling. Water cement ratio and inert materials amount were rationally regulated for hole sealing by grouting cement slurry inside the drill pipe to ensure the sealing efficiency and quality. The above various wall protection technologies show obvious effects, they can be widely popularized.