Analysis was made on the technical advantages in solving the difficulties of geological uncertainty and complicated surface environment. Based on the analysis on the setting position of casing program of Puguang gas field, the scope of casing setting depth was determined. Then 2 sets of well structure scheme were proposed for horizontal well in Puguang gas field. Take the Puguang 105 cluster well platform for an example, the well structure of 105-1 and 105-2 were optimized, and the drilling results were summarized and analyzed. The practice shows that cluster well could shorten the cycle of drilling, reduce the failure caused by complicated situation and improve drilling efficiency.