As one of the horizontal wells in the project of Turkish Beypazari trona solution mining Phase Ⅲ, H001LA is complicated in well layout comprising different main trona seams and varieties of well units styles in the design. Many difficulties encountered during the construction process such as loss of main trona seam, serious undulation of the formations, brine outflow, drilling to large cavity and formation collapsing. By the comparison analysis on the 3 feasible construction schemes, one was adopted with low cost, short construction period, high safety coefficient and successful well completion.