The borehole accident frequently occurred in the whole mount exploration in Baima vanadium-titanium of Panzhihua area with leakage in upper part and fault fracture zone in lower part. The low drilling efficiency brought along seriously affected the exploration construction. According to this difficult problem, by the repeated tests and studies, a set of effective wall protection and leakage control technical system was developed to ensure the successful accomplishment of whole mount exploration. Mudding leakage control and wall protection technology and the effect in this area were presented.