Bionic impregnated diamond bit has the characteristics of high efficiency and wear resistance, which meets the requirements of the exploration of natural gas hydrate and the conditions of the construction site in Mohe. This paper introduces the design and manufacturing of bionic impregnated diamond bit suitable to the characteristics of Mohe formation. The paper analyzes the drilling conditions of nonideal bit and puts forward the comprehensive analysis for evaluation of bit performance to objectively and truly reflect the actual bit drilling capacity. The drilling results of MK-2 scientific drilling test well of Mohe natural gas hydrate indicate that the service life and the drilling speed of bionic impregnated diamond bits are 73% longer and 22% higher than ordinary diamond impregnated diamond bits.