According to the drilling difficulties in Liuguan Pb-Zn mining area in Henan, by optimizing borehole structure and putting retrievable casing in the upper complex hole section, the construction schedule was accelerated; with low pressure and slow speed wire-line coring hydro-hammer technology, the obvious effects of drilling deviation control and less borehole curvature were received, the construction quality and success rate were improved. Based on the field analysis，mud formulation was constantly adjusted and inert leaking stoppage material was added to different loss zones. A set of wall protection and leaking stoppage technology suitable for the complex formation of this mining area was developed.