The common used positive circulation drilling for present large diameter well drilling construction has the disadvantages of low mud flow velocity, poor particle carrying ability, serious breaking repetition, low drilling efficiency, severe drill bit wearing, high energy consumption and high accident rate, which can be effectively improved by air-lift reverse circulation drilling technology. The ventilation pipe air-lift reverse circulation drilling technology is simple and easy to apply; it can effectively reduce the breaking repetition with high drilling efficiency, less energy consumption, long bit service life, good well quality and strong inhibition of water gushing and leakage. The paper introduces the ventilation pipe air-lift reverse circulation drilling technology about its principle, the special drilling tools and the field application.