Because of the complex regional tectonics with broken rocks, kaolinization in part of rocks, serious circulation loss and collapse in Huaishuping large gold mine, the downhole accidents of hole diameter shrinkage, drill pipe sticking and difficult inner tube assembly fishing often occurred, which seriously affected the drilling efficiency and drilling quality. The analysis on the above difficulties and problems are made, and by the experimental study, the low solids polymer mud system is adopted. According to the characteristics of the strata, the formula of low solid phase polymer mud, preparation method, maintenance and wall protection & plugging under different conditions are determined and gradually comprehensive promoted in this mining area. The hole accidents are greatly reduced with the efficiencies of penetration and meterage per rig-month improved, which also promotes the mining exploration progress, shortens the cycle of exploration and achieves remarkable economic and social benefits.