3D entity model was set up for TGLW 220 660 flushing fluid centrifuge drum that is self-developed and used in geological drilling; using finite element analysis software, 3D finite element analysis and simulation were made on the whole structure of the drum under normal working conditions. The simulation analysis results show that the strength of the centrifuge drum under the normal working conditions can meet the construction requirements and the strength checking based on traditional theory further validates the rationality and reliability of rotary drum design, which provides the important theory basis for the safe use of TGLW 220 660 centrifuge in construction site.