In order to cope with accidents of hole deviation and drill pipe sticking in 100m deep horizontal drilling construction, wire-line coring technology was applied by testing in 2 engineerings. By replacing flexible steel wire in fisher with iron pipe, the fishing and lowering of inner-tube assembly are solved. No accidents occurred in these 2 wells, and good drilling effect is achieved with high drilling efficiency and high coring rate. With the engineering cases, the paper introduces the technical requirements and process measures of wire-line coring drilling technology applied in horizontal well.